Dynamics of Biological Macromolecules
Activity and function of biological systems are defined by their dynamics. Understanding the basic parameters that control molecular motions in biological systems, and understanding the relationship between molecular dynamics and biological functions are the main goals of our research in this direction. Among major topics, we also study role of solvents in protein dynamics, activity and stability and we are developing formulations for long-term preservation of biological molecules. We use neutron, light scattering and dielectric spectroscopy, and we actively collaborate with groups performing MD-simulations.
Recent Most Important Publications
S. Khodadadi, J. H. Roh, A. Kisliuk, E. Mamontov, M. Tyagi, S. A. Woodson, R. M. Briber, A. P. Sokolov, Dynamics of Biological Macromolecules: Not a Simple Slaving by Hydration Water, Biophys.J. 98, 1321 (2010).
S. Khodadadi, A. Malkovskiy, A. Kisliuk, A.P. Sokolov, A broad glass transition in hydrated proteins, BBA – Proteins and Proteomics 1804, 15 (2010).
J. H. Roh, R. M. Briber, A. Damjanovic, D. Thirumalai, S. A. Woodson, A. P. Sokolov, Dynamics of tRNA at Different Levels of Hydration. Biophys.J. 96, 2755 (2009).
S. Pawlus, S. Khodadadi and A. P. Sokolov, Conductivity in Hydrated Proteins: No Signs of the Fragile-to-Strong Crossover, Phys.Rev.Lett. 100, 108103 (2008).
Sheila Khodadadi, Sebastian Pawlus, Alexei Sokolov, Influence of Hydration on Protein Dynamics: Combining Dielectric and Neutron Scattering Spectroscopy Data. J. Phys. Chem. B 112, 14273 (2008).
S. Khodadadi, S. Pawlus, J.H. Roh, V. Garcia Sakai, E. Mamontov, A.P. Sokolov, The Origin of the Dynamic Transition in Proteins, J.Chem.Phys. 128, 195106 (2008).
Gokhan Caliskan, Robert M. Briber, D. Thirumalai, Victoria Garcia-Sakai, Sarah A. Woodson, Alexei P. Sokolov, “Dynamic Transition in tRNA is Solvent Induced”, J.Amer.Chem.Soc. 128, 32 (2006).
J. H. Roh, J. E. Curtis, S. Azzam, V. N. Novikov, I. Peral, Z. Chowdhuri, R. B. Gregory and A. P. Sokolov, “Influence of Hydration on the Dynamics of Lysozyme”, Biophys. J. 91 2573-2588 (2006).
J.H. Roh, V.N. Novikov, R.B. Gregory, J.E. Curtis, Z. Chowdhuri, A.P. Sokolov, “Onsets of Anharmonicity in Protein Dynamics”, Phys.Rev.Lett. 95, 038101 (2005).
G. Caliskan, D. Mechtani, S. Azzam, J.H. Roh, A. Kisliuk, M.T. Cicerone, S. Lin-Gibson, I. Peral and A.P. Sokolov, Protein and Solvent Dynamics: How Strongly Are They Coupled?, J.Chem.Phys. 121, 1978 (2004).